Fluoride & Remin Meta-analysis ✓ Peer reviewed

The cytotoxic and biological effects of silver diamine fluoride on human dental pulp cells: A systematic review and meta-analysis.

Journal of oral biology and craniofacial research · Kumari C, Singhal R, Namdev R, Kumar A, Chawla S, Chhanna K · 2026-11-01

A systematic review analysing in vitro studies found silver diamine fluoride demonstrates dose-dependent toxicity to human dental pulp cells, with clinically used concentrations causing marked reductions in cell viability, suggesting caution when applying standard formulations near the pulp.

A plain-English summary of the study's own findings — we don't add our own claims or interpretation. Read the full paper for the complete methods and results, and apply your own clinical judgement.

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