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Porphyromonas gingivalis Promotes Lipid Droplet–Mediated Microglial Dysfunction

Journal of Dental Research · M.S. Riaz Rajoka, K.N. Valladares, C.L. Prairie, W. Li, P. King, J. Katz, S.M. Michalek, P. Zhang · 2026-09-24

A periodontal pathogen triggered lipid droplet buildup in microglial cells, impairing their ability to clear debris and increasing harmful oxidative stress; blocking lipid droplet formation reversed these effects and restored normal microglial function.

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