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Effect of Silica-Based Abrasive Ingredients on Fluoride Concentration in Toothpaste: An In Vitro and In Vivo Study.

Dentistry journal · Hamaguchi S, Akitomo T, Ogawa M, Kusaka S, Nomura R · 2026-09-10

Researchers measured oral fluoride levels after using toothpastes with varying amounts of silica-based abrasives, finding that toothpaste without abrasive ingredients maintained higher fluoride concentrations in the mouth and released more fluoride from tooth-like mineral surfaces.

A plain-English summary of the study's own findings — we don't add our own claims or interpretation. Read the full paper for the complete methods and results, and apply your own clinical judgement.

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