Perio & Hygiene Systematic review ✓ Peer reviewed

The Role of Regulatory T Cells in Periodontitis With or Without Systemic Diseases: A Systematic Review.

International journal of molecular sciences · Inchingolo AM, Fatone MC, Marinelli G, Ferrante L, Calò F, Palermo A, Severino M, Inchingolo F, Inchingolo AD, Dipalma G · 2026-09-21

A systematic review examined how regulatory T cells function in periodontitis, both with and without systemic diseases, finding that their balance with other immune cells and their cytokine profiles differ from healthy individuals—though evidence does not yet support targeted therapeutic approaches.

A plain-English summary of the study's own findings — we don't add our own claims or interpretation. Read the full paper for the complete methods and results, and apply your own clinical judgement.

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