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Dual-Biomarker Oral-Rinse Testing for aMMP-8 and Calprotectin: A Potential Adjunctive Tool for Risk Stratification and Interdisciplinary Referral in Periodontitis and Type 2 Diabetes.

Bioengineering (Basel, Switzerland) · Leone P, Räisänen IT, Thomas JT, Pärnänen P, Anil S, Grigoriadis A, Sakellari D, di Silverio P, Evangelista M, Sorsa T · 2026-09-08

A narrative review found that oral-rinse testing for two inflammation markers (aMMP-8 and calprotectin) may help identify active periodontitis and support referral decisions, though aMMP-8 performs better individually and standardized protocols are needed before widespread clinical use.

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