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Salivary Melatonin and MMP-9 Levels in Stage III Periodontitis: A Pilot Study Using Standardized Pre-Sleep Saliva Collection.

Medicina (Kaunas, Lithuania) · Ivanov I, Naseva E, Mlachkova A, Dosseva-Panova V, Pashova-Tasseva Z, Maynalovska H, Kirilov B, Petrova V, Ishkitiev N, Apostolova S · 2026-09-13

Researchers compared salivary melatonin and MMP-9 levels in people with stage III periodontitis versus periodontally healthy individuals, finding significantly lower melatonin in the periodontitis group but no significant difference in MMP-9, with melatonin showing preliminary potential to distinguish between the two conditions.

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