Special Needs & Medical Systematic review ✓ Peer reviewed

Salivary adjunct tests to determine the need for biopsy for early detection of oral squamous cell carcinoma and potentially malignant disorders: An evidence summary of a living systematic review, Version 2026 1.0.

Journal of the American Dental Association (1939) · Martins-Pfeifer C, Bhosale AS, Urquhart O, Verdugo-Paiva F, Lee GH, O'Brien KK, Rojas-Gómez AM, Glick M, Lingen MW, Chaturvedi AK, Carrasco-Labra A · 2026-09-28

Researchers searched for evidence on salivary tests to help identify oral cancer and pre-cancerous conditions before biopsy. They found only one small study examining four salivary biomarkers, which showed moderate sensitivity and specificity but was poorly reported and unsuitable for guiding clinical practice.

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