Adjunctive Effects of a 2% Zinc Citrate Toothpaste on Plaque and Oral Microbiota in Orthodontic Patients: A Randomized Controlled Trial.
A trial compared a toothpaste containing 2% zinc citrate to standard toothpaste in orthodontic patients with plaque-induced gingivitis, measuring gingival inflammation, plaque levels, and bacterial load over 4 weeks. While the zinc citrate group showed lower inflammation and plaque at week 4, longitudinal analysis found no significant additional benefit from the zinc citrate toothpaste.
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