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From Inflamed Gingiva to Invasive Malignancy: Molecular Crosstalk in Oral Carcinogenesis: A Scoping Review.

Frontiers in bioscience (Landmark edition) · Jovanova E, Angjelova A, Campagna R, Polizzi A, Marya A, Isola G · 2026-09-07

A scoping review of 46 studies found that periodontal pathogens like *Porphyromonas gingivalis* and *Fusobacterium nucleatum* may trigger molecular pathways linked to oral squamous cell carcinoma development through inflammatory signalling, immune suppression, and cellular changes promoting tumour invasion.

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