Paediatric & MIH Study ✓ Peer reviewed

Comparative evaluation of the anesthetic efficacy of 4% buffered articaine versus 2% un-buffered lidocaine for dental injections in children: a double-blind randomized parallel group control trial.

Journal of dental anesthesia and pain medicine · Suresh A, Tirupathi SP · 2026-08-01

Researchers compared buffered 4% articaine with standard 2% lidocaine in children aged 6–12 years undergoing dental procedures, finding that buffered articaine produced less injection pain, faster numbing onset, and better operator experience, while both agents showed similar safety profiles.

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