Special Needs & Medical Observational ✓ Peer reviewed

Edentulism, blood-based neurodegenerative biomarkers, and 10-year dementia risk: A mediation analysis in a nationally representative United States cohort.

Alzheimer's & dementia : the journal of the Alzheimer's Association · Qi X, Liu R, Belsky DW, Tian Q, Luo H, Liu Y, Xu Z, Langa KM, Wu B · 2026-08-01

Among US adults aged 50+, tooth loss was linked to higher levels of two brain-injury markers (neurofilament light chain and glial fibrillary acidic protein) and increased dementia and cognitive impairment risk over 10 years; these biomarkers explained only a small portion of this association.

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