Sirtuin 4 is downregulated in oral carcinogenesis.

Researchers compared SIRT4 protein levels across benign oral tissue, dysplastic lesions, and oral cancer, finding significantly lower SIRT4 expression in dysplastic and cancerous tissue, suggesting it may function as a tumor suppressor and early biomarker for oral malignancy.

A plain-English summary of the study's own findings — we don't add our own claims or interpretation. Read the full paper for the complete methods and results, and apply your own clinical judgement.