Association of phenotypic and functional characteristics of regulatory T cells from minor salivary glands with expression of the delta 7 FoxP3 splice variant in patients with Sjögren's disease.
Researchers examined regulatory T cells from Sjögren's disease patients and found that elevated expression of a specific FoxP3 variant (Δ7) was linked to reduced suppressive function, lower levels of protective molecules and cytokines, and characteristics of immature cells.
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