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Senescent CD4+ T Cells Drive Diabetic Periodontitis via JAK-STAT-ROS-p38 MAPK

Journal of Dental Research · M. Zhang, L. Meng, X. Li, Y. Zhang, R. Yuan, S. Liu, H. Liu, M. Li · 2025-12-18

Researchers found that ageing CD4+ immune cells drive diabetic periodontitis by activating specific cellular signalling pathways (JAK-STAT and p38 MAPK), which generate damaging inflammatory responses and bone loss. Blocking these pathways reduced immune cell ageing in laboratory studies.

A plain-English summary of the study's own findings — we don't add our own claims or interpretation. Read the full paper for the complete methods and results, and apply your own clinical judgement.

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