Mesenchymal Clock Regulates TMJ Homeostasis and Lipid Metabolic Rhythms with Age

Researchers found that the circadian clock in mesenchymal cells protects TMJ cartilage and bone during aging by regulating a protein called PRG4 and controlling inflammatory signalling. Administering PRG4 at night—its peak natural time—partially restored cartilage integrity in aged mice and those lacking the circadian regulator Bmal1.

A plain-English summary of the study's own findings — we don't add our own claims or interpretation. Read the full paper for the complete methods and results, and apply your own clinical judgement.