Other Research Study ✓ Peer reviewed

The Role of the Kynurenine Pathway in Irreversible Pulpitis

Journal of Dental Research · J. Coulter, C.J. Nile, H. Lemos, P. LoCoco, J. Whitworth, R.A. Valentine, A. Diogenes, C. Chang, A. Mellor, V. Telezhkin, J. Durham · 2026-03-09

Researchers found that the enzyme IDO and the kynurenine pathway were significantly elevated in irreversible pulpitis samples and linked to pain-promoting neuroinflammatory processes, suggesting this pathway may contribute to pulpitis-associated pain.

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