Target Trial Emulation to Assess Oral Drug Safety

Researchers used target trial emulation methodology on electronic health records to compare whether thiazide versus non-thiazide blood pressure medications differently affected dental caries risk over 5 years, finding no significant difference between groups while demonstrating how this approach reduces bias compared to standard observational study designs.

A plain-English summary of the study's own findings — we don't add our own claims or interpretation. Read the full paper for the complete methods and results, and apply your own clinical judgement.