Other Research Study ✓ Peer reviewed

MFN2–PERK Axis Regulates ER Stress in Parotid Glands of Aged Mice via MAMs

Journal of Dental Research · Y. Chen, Y.M. Xu, L.L. Zhu, Z.Y. Shan, Z.G. Yao, H. Zhao · 2026-03-28

Aged mice showed deterioration of parotid gland structure and function linked to disrupted connections between mitochondria and the endoplasmic reticulum, with reduced MFN2 protein and activated PERK signalling contributing to cellular stress; two compounds reversed these changes.

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