Other Research Study ✓ Peer reviewed

FSTL3-Driven Cuproptosis Resistance and EPCs Promote OSCC Metastasis

Journal of Dental Research · S.-R. Li, Z.-Z. Wu, W.-D. Wang, W.-T. Mo, Q. Wang, E.-L. Yang, W.-Y. Wang, Q.-C. Yang, H. Li, T.-F. Wu, Z.-J. Sun · 2026-04-17

Researchers identified FSTL3 as a key driver of oral cancer spread to lymph nodes through two mechanisms: helping cancer cells resist a form of cell death and suppressing immune responses by recruiting immunosuppressive cells. Blocking FSTL3 combined with immunotherapy showed promise in preventing metastasis.

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