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Sustained-Release RANKL Microneedles for Safe Orthodontic Acceleration

Journal of Dental Research · W. Qu, C. Zhan, Q. Dai, J. Yan, C. McGrath, B. Han, Z. Ye, Y. Lin · 2026-05-27

Researchers developed microneedle patches containing RANKL to accelerate orthodontic tooth movement in rats. The patches provided sustained drug release with better safety profiles than direct injection, causing less root resorption while still effectively stimulating bone remodeling.

A plain-English summary of the study's own findings — we don't add our own claims or interpretation. Read the full paper for the complete methods and results, and apply your own clinical judgement.

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