Caspase-8 Mutation Promotes HNSCC Development and Resistance to Anti–PD-1

Mice engineered with a caspase-8 mutation found in head and neck cancers developed more tumours and showed resistance to anti-PD-1 immunotherapy, with reduced immune cell infiltration compared to wild-type controls.

A plain-English summary of the study's own findings — we don't add our own claims or interpretation. Read the full paper for the complete methods and results, and apply your own clinical judgement.