Enhancer Regulation of OSR2 in Mandibular Incisor Agenesis Susceptibility

Researchers identified a genetic variant that increases the risk of congenitally missing mandibular incisors by affecting how OSR2 gene expression is regulated, which in turn disrupts normal tooth development processes through the CXCR4 pathway.

A plain-English summary of the study's own findings — we don't add our own claims or interpretation. Read the full paper for the complete methods and results, and apply your own clinical judgement.