Other Research Study ✓ Peer reviewed

WNT Signaling Modifies Barrier Functions of Junctional and Pocket Epithelium

Journal of Dental Research · F. Aellos, E. Chang, E. Jeong, B. Liu, X. Yuan, R. Nazari, F. Hermans, M.M. Torabi, P.C. Ochweri, P. Cuevas, S. Rao, K.A. Apaza Alccayhuaman, A. Sandoval, B.R. Coyac, I. Lambrichts, J.A. Helms · 2026-07-18

Ligature-induced periodontitis disrupted barrier proteins in junctional epithelium and converted it to pocket epithelium through a Wnt-signaling-dependent mechanism; topical WNT3A treatment partially restored barrier features in compromised pocket epithelium.

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