Other Research Study ✓ Peer reviewed

Prevotella intermedia–Derived Extracellular Vesicles Promote Pulpitis

Journal of Dental Research · Q. Lei, X. Zou, X. Luo, X. Han, Y. Chen, S. Tan, B. Wen, S. Liu, D. Ma · 2026-07-25

Researchers identified that extracellular vesicles from *Prevotella intermedia* bacteria trigger pulpitis by causing macrophage death, leading to inflammation in dental pulp cells through a specific molecular pathway involving interleukin-33 and cellular stress responses.

A plain-English summary of the study's own findings — we don't add our own claims or interpretation. Read the full paper for the complete methods and results, and apply your own clinical judgement.

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