Lipocalin-2 inhibition regulates pain-like facial expression associated with neuroinflammation involving the NF-κB/β-catenin pathway during orthodontic tooth movement in a type 2 diabetic model.

Blocking Lipocalin-2 in diabetic mice undergoing orthodontic tooth movement reduced pain-related facial expressions and neuroinflammation in the brain, while decreasing excessive tooth displacement and periodontal changes.

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