Growth differentiation factor 15 impairs periodontal ligament stem cell proteostasis via integrated stress response to drive diabetic periodontitis.

Researchers found that GDF15 protein impairs stem cell function in the periodontal ligament of diabetic mice by triggering a stress response pathway, reducing bone-forming capacity and tissue regeneration—effects that were reversed when GDF15 was blocked or the stress pathway was inhibited.

A plain-English summary of the study's own findings — we don't add our own claims or interpretation. Read the full paper for the complete methods and results, and apply your own clinical judgement.