Prevention & Diet Meta-analysis ✓ Peer reviewed

Platelet-rich fibrin for the prevention of medication-related osteonecrosis of the jaw after tooth extraction: a systematic review and meta-analysis.

Oral and maxillofacial surgery · Sampaio P, Shazo S, Vellone V, Silva LB · 2026-07-16

Researchers reviewed studies comparing tooth extraction with platelet-rich fibrin versus extraction alone in patients on medications causing bone loss or preventing new blood vessel formation. They found PRF was associated with lower medication-related jaw osteonecrosis risk and better healing, though evidence certainty was very low.

A plain-English summary of the study's own findings — we don't add our own claims or interpretation. Read the full paper for the complete methods and results, and apply your own clinical judgement.

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