Caries & Minimal Intervention Randomised controlled trial ✓ Peer reviewed

Clinical and radiographic comparison of minimally invasive nonsurgical and surgical approaches with enamel matrix derivatives in periodontal intrabony defects: a 3-arm randomized clinical trial.

Journal of periodontal & implant science · Park SH, Kim DM, Song YW, Park JY, Jung UW · 2026-06-15

Researchers compared three approaches for treating periodontal bone defects: nonsurgical cleaning alone, minimally invasive surgery with enamel matrix derivative, and nonsurgical cleaning with enamel matrix derivative. At 6 months, nonsurgical treatment with the derivative showed comparable outcomes to surgical treatment, with less bleeding on the gums.

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