Perio & Hygiene Study ✓ Peer reviewed

Comparative evaluation of dickkopf-1 levels in gingival crevicular fluid before and after nonsurgical therapy in type 2 diabetics and smokers with periodontal disease.

Journal of Indian Society of Periodontology · Jayachandiran M, Ravindran SK, Balu P, Muthu J, Ramkumar N, Sathiyaseelan S, Senthil D · 2026-04-01

Researchers measured dickkopf-1 protein in gum fluid from periodontitis patients with diabetes or smoking habits before and after nonsurgical treatment, finding it was elevated at baseline and decreased significantly after therapy, though remaining higher than healthy controls.

A plain-English summary of the study's own findings — we don't add our own claims or interpretation. Read the full paper for the complete methods and results, and apply your own clinical judgement.

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