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Imbalanced p53-RB signaling triggers cGAS-STING-mediated immune activation in early oral cancer development.

Oncogene · Lu Z, Mouri Y, Shao W, Yasue A, Wang C, Hagita H, Yamamoto K, Matsumoto N, Matsumoto M, Oya T, Kudo Y · 2026-08-15

Mice with partial loss of two key tumor suppressors showed increased immune activation through a specific signaling pathway, delaying cancer development, while human cancer data confirmed these genetic changes affect survival outcomes.

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