Caries & Minimal Intervention Study ✓ Peer reviewed

Radiation-related caries in oral cancer: Molecular pathogenesis, cellular mechanisms, and contemporary management paradigms.

Journal of cancer research and therapeutics · Soi S, Sharma M, Sushant S, Mrinalini M, Saini SK, Dave A, Sharma D · 2026-04-01

Radiation-related caries in oral cancer patients involves multiple mechanisms including reduced saliva, direct tooth damage, enzyme activation, and microbial shifts. Prevention and management strategies range from salivary-sparing radiotherapy to emerging therapies like antimicrobial peptides and artificial intelligence-assisted diagnosis.

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