Other Research Study ✓ Peer reviewed

Dental Pulp Stem Cells Transfer Mitochondria via Tunneling Nanotubes to Drive Hypoxic Angiogenesis

Journal of Dental Research · S. Yang, J. Liu, D.S. Thalakiriyawa, J. Liu, X. Yang, C.K.Y. Yiu, W.L. Dissanayaka · 2026-08-21

Dental pulp stem cells transfer mitochondria to blood vessel cells through tiny tunneling structures, protecting these cells from death under low-oxygen conditions and promoting new blood vessel formation. This mitochondrial transfer activates a cellular signalling pathway that supports vessel growth in the oxygen-poor dental pulp environment.

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