Fluoride & Remin Study ✓ Peer reviewed

Zinc-stabilized stannous fluoride modulates the periodontal microbiome, reducing Fusobacteria, key Gram-negative species, and overall inflammation within an experimental gingivitis clinical trial.

Journal of periodontology · Kerns KA, Naumann AA, Soon LY, Hendrickson EL, Barbour A, Chen D, Trivedi HM, Glogauer M, McLean JS · 2026-07-31

A zinc-stabilized stannous fluoride toothpaste reduced harmful Gram-negative bacteria—including Fusobacterium nucleatum—in subgingival plaque and decreased gingival inflammation compared to standard sodium fluoride toothpaste during a 21-day experimental gingivitis trial.

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