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Polygenic Risk Modelling in Periodontitis: Insights From a Feasibility Study of 4243 European Cases and Current Limitations.

Journal of clinical periodontology · Richter GM, Akinloye OM, Nasr MK, Holtfreter B, de Coo A, Almeida SD, Loos BG, Jepsen S, Dommisch H, Bruckmann C, Kapferer-Seebacher I, PerioGEN Cohort Group, Homuth G, Kocher T, Völzke H, Berger K, Laudes M, Lieb W, van der Velde N, van Schoor N, de Groot L, Blanco J, Carracedo A, Cruz R, Dempfle A, Teumer A, Schaefer AS, Freitag-Wolf S · 2026-08-21

Researchers developed a polygenic score to predict severe periodontitis risk using existing genetic data from European populations, but found the score had poor ability to distinguish cases from controls, indicating current genetic information is insufficient for reliable risk prediction.

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