Other Research Randomised controlled trial ✓ Peer reviewed

Mucoadhesive patch versus benzocaine gel for reducing injection pain: a split-mouth randomized clinical trial.

Oral and maxillofacial surgery · Sahebalam R, Sheibani A, Bagheri H, Eshghpour M, Zahabi E, Rajabi N, Hoseinzadeh M · 2026-08-21

A split-mouth trial compared a novel bilayer mucoadhesive benzocaine patch with benzocaine gel for reducing injection pain in 36 patients undergoing bilateral extractions. The patch resulted in significantly lower self-reported pain for both injection sites and lower observer-rated pain at the palate compared to the gel.

A plain-English summary of the study's own findings — we don't add our own claims or interpretation. Read the full paper for the complete methods and results, and apply your own clinical judgement.

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