Perio & Hygiene Meta-analysis ✓ Peer reviewed

Changes in Serum C-Reactive Protein Following Nonsurgical Periodontal Therapy: A Systematic Review and Meta-Analysis.

Journal of clinical medicine · Montoya-Carralero JM, Ávila-Villasmil R, Romo-García MF, Jornet-García A, Sánchez-Pérez A, Moya-Villaescusa MJ · 2026-08-12

Nonsurgical periodontal therapy reduced serum C-reactive protein by approximately 1.11 mg/L in uncontrolled studies, but controlled trial evidence was too limited to confirm this represents a genuine treatment effect rather than natural variation.

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