Perio & Hygiene Study ✓ Peer reviewed

Delayed shifts in salivary microbiota composition following long-term use of 0.06% chlorhexidine toothpaste.

Frontiers in oral health · Chuchmova V, Brodíková K, Zapletalova M, Lindholm M, Krsek M · 2026-08-11

Long-term use of 0.06% chlorhexidine toothpaste altered salivary microbial community structure in healthy individuals, with significant shifts appearing after stopping the product, including delayed increases in gram-negative bacteria and reduced predicted antibiotic resistance pathways.

A plain-English summary of the study's own findings — we don't add our own claims or interpretation. Read the full paper for the complete methods and results, and apply your own clinical judgement.

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