Perio & Hygiene Meta-analysis ✓ Peer reviewed

Efficacy of Ozonated Gels and Oils As Adjunctive or Monotherapy in Periodontitis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Clinical and experimental dental research · Bahrami M, Etemadi M, Abrishami R, Alipour F, Hadizadeh S, Jamshidian F, Abedinzadeh N, Akbari A, Pordel E · 2026-08-01

A systematic review of 19 randomised controlled trials found that ozonated gels and oils reduced probing pocket depth and clinical attachment loss when combined with subgingival instrumentation, but showed no clear advantage over chlorhexidine or benefit on plaque and gingival indices.

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