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Salivary Aldosterone as a Biomarker for Obstructive Sleep Apnea: Diagnostic Performance and the Moderating Role of Mean Arterial Pressure-A Cross-Sectional Study.

Clocks & sleep · Chen Z, Lau MN, Tengku Hamzah TNN, Abd Rahman ANA, Goh LC, Wey MC · 2026-08-17

Researchers measured morning salivary aldosterone in 67 adults with varying OSA severity and found it performed poorly as a standalone diagnostic marker, though mean arterial pressure appeared to moderate the relationship between OSA and aldosterone levels. Age independently predicted lower aldosterone, while the STOP-BANG questionnaire showed superior diagnostic performance.

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