Perio & Hygiene Randomised controlled trial ✓ Peer reviewed

Vitamins A- and C-augmented platelet-rich fibrin in periodontal intraosseous defects: A randomized clinical trial.

Journal of periodontology · Sanaa D, Elbattawy W, Hassan A, Magdeldin S, Mokhtar M, Abdelmoneim TK, Fawzy El-Sayed K · 2026-07-29

Researchers compared vitamin A and C–enhanced injectable platelet-rich fibrin with standard injectable platelet-rich fibrin, both combined with minimally invasive surgery, for treating bone defects in periodontitis patients. The vitamin-augmented approach produced greater improvements in bone fill and clinical attachment level at six to nine months.

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