Special Needs & Medical Randomised controlled trial ✓ Peer reviewed

Pilocarpine Drops for Xerostomia in Patients With a Life-Limiting Condition or Frailty: A Double-Blind Placebo-Controlled Randomized Clinical Trial.

Journal of the American Medical Directors Association · van der Meulen A, Gulikers J, Theunissen M, van Kuijk S, Kimman M, Coenegracht B, Stoppelenburg A, van der Linden Y, van den Beuken-van Everdingen M · 2026-08-25

Topical pilocarpine drops did not significantly reduce dry mouth severity compared to placebo in frail or seriously ill patients, though pilocarpine showed continued improvement between weeks two and four with few side effects.

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