Other Research Study ✓ Peer reviewed

Lack of Efficacy of Low-Dose Cyclobenzaprine on Electromyographic Activity Related to Sleep Bruxism: A Randomized Crossover Double-Blind Placebo-Controlled Clinical Trial.

Journal of sleep research · Herreira-Ferreira M, Fabbro CD, Lavigne GJ, Stuginski-Barbosa J, Svensson P, Conti PCR, Bonjardim LR · 2026-08-29

Researchers tested whether a low dose of cyclobenzaprine reduced sleep bruxism-related muscle activity in a placebo-controlled trial of 20 participants, finding the medication did not significantly decrease jaw muscle contractions, bite force, or self-reported bruxism symptoms.

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