Other Research Study ✓ Peer reviewed

Abnormal Enamel Mineralization and Hypercalcemia due to GNA11 Variants

Journal of Dental Research · N. Obtel, A. Le Cabec, A.-L. Lakhel, A. Attia, C. Andrique, F. Hermans, F. Kovaci, T.N. Nguyen, A. Chansavang, A. Percot, C. Torrens, D. Vangu, F. Vaysse, M. Gadion, F. Savagner, T. Edouard, A. Bloch-Zupan, B. Lukić, A. Rack, A. Brunelle, A. Linglart, E. Pasmant, F. Ramirez Rozzi, F.M. Hannan, C. Gaucher, T. Coradin, R.V. Thakker, J.-P. Bertocchio, C. Chaussain · 2026-08-31

Researchers identified GNA11 gene mutations causing high blood calcium levels alongside abnormal enamel mineralization in two families. Mouse models confirmed that GNA11 loss of function impairs enamel mineralization, suggesting dental assessment should be part of calcium disorder management.

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