Epigenetic Connections in Malocclusion.

A review examined how epigenetic mechanisms—chemical modifications that regulate gene expression—may contribute to malocclusion development and orthodontic tooth movement. While laboratory and animal studies suggest epigenetic processes respond to mechanical forces and influence bone and tissue remodeling, direct evidence linking specific epigenetic changes to human malocclusion remains scarce, limiting current clinical application.

A plain-English summary of the study's own findings — we don't add our own claims or interpretation. Read the full paper for the complete methods and results, and apply your own clinical judgement.