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When Clinical Suspicion Outweighs a Negative Biopsy: Early Tongue Squamous Cell Carcinoma Diagnosed After Persistent Oral Leukoplakia.

Cureus · Reboredo P, Nogueira P, Boer N, Cereja F, Barbosa I, Sousa C · 2026-08-06

A man with persistent tongue leukoplakia and weight loss had an initial negative biopsy but later developed invasive squamous cell carcinoma, demonstrating that clinical suspicion should prompt further investigation even when biopsy results are negative.

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