Effect of In-Office Whitening Gels Acidity on Tooth Sensitivity, Color Change, and Gingival Irritation in Patients with Fixed Orthodontic Appliances: A Randomized Clinical Trial.
Researchers compared two 35% hydrogen peroxide in-office whitening gels—one acidic and one neutral-to-alkaline—in orthodontic patients, finding the neutral-to-alkaline formulation caused less tooth sensitivity while producing similar whitening and gingival effects.
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