Perio & Hygiene Study ✓ Peer reviewed

Heat-treatment-programmed NiTi-5Cu (AH) bioactive orthodontic alloy enables Cu release for antibiofilm and periodontal protection in diabetic oral microenvironment.

Biomaterials · Wang L, Fang Y, Zhang S, Lei P, Ma J, Jin L, Wang W, Yang Q, Wang Y, Zhao C, Yang K, Yin H, Chen R, Wang G, Chen J, Ren L, Sun D · 2026-07-25

Researchers developed a heat-treated nickel-titanium-copper orthodontic alloy that releases copper to fight bacteria and protect periodontal health in diabetic patients, demonstrating antibacterial activity and bone-protective effects in a diabetic rat model without harming oral cells.

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