Tissue-based genomic instability markers for predicting malignant transformation in oral leukoplakia and proliferative verrucous leukoplakia: a systematic review.
This systematic review examined tissue-based genomic markers in 34 studies (3,237 patients) to assess their ability to predict which oral leukoplakias and proliferative verrucous leukoplakias progress to cancer. Several genomic alterations showed associations with malignant transformation in oral leukoplakias, but no single marker was sufficiently predictive; combined marker panels integrated with clinical factors may offer promise.
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