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Spatiotemporal orchestration of the salivary gland immune microenvironment in Sjögren's disease: a multidimensional framework of epithelial licensing, lymphoid neogenesis, and stromal remodeling.

Frontiers in immunology · Ren S, Li Q, Niu R, Liu X, Zhou P, Yang X, Liang H · 2026-07-15

Researchers propose a tissue-focused framework for understanding Sjögren's disease progression, identifying three overlapping dimensions of salivary gland changes—epithelial activation, lymphoid organisation, and structural remodeling—to better match treatments to individual disease stages and tissue states.

A plain-English summary of the study's own findings — we don't add our own claims or interpretation. Read the full paper for the complete methods and results, and apply your own clinical judgement.

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