Paediatric & MIH Study ✓ Peer reviewed

Effects of salivary proteinase 3 and oxidative stress markers on secondary caries following pit-and-fissure sealants in patients with S-ECC.

Annals of medicine and surgery (2012) · Xia S, Wang G · 2026-08-06

Researchers tracked salivary biomarkers in young children with severe early childhood caries who received sealants, finding that lower proteinase 3 and oxidative stress markers were associated with developing secondary caries over 12 months.

A plain-English summary of the study's own findings — we don't add our own claims or interpretation. Read the full paper for the complete methods and results, and apply your own clinical judgement.

Read the full study at the source
The Recall — the month's most significant new dental research, summarised. Free.
Browse The Recall